Breast Health and Chemicals with Dr. William H. Goodson III, MD – The Smart Human Podcast Episode #32

Dr. Goodson grew up in Missouri and graduated from the University of Missouri Columbia and Harvard Medical School. He trained as a general surgeon and specialized in breast surgery before it was a recognized field. He was a member of the research group that established breast conservation, i.e., lumpectomy, as the preferred treatment for early breast cancer. Recognizing that he was treating more young women with breast cancer, he joined with Dr. Shanaz Dairkee in 2005 to investigate how common environmental chemicals such as BPA, methylparaben, PFOA, etc. disrupt the normal biology of non-cancerous, human breasts. He has been a professor at the University of California San Francisco and a Senior Scientist at the California Pacific Medical Center Research Institute. He is a fellow of the American College of Surgeons, a member of the American Society for Clinical Oncology, and a spokesperson for The Halifax Project. In addition to research, he enjoys photography, writing, and creating hand-drawn animation as on his website,

A Ternary Mixture of Common Chemicals Perturbs Benign Human Breast Epithelial Cells More Than the Same Chemicals Do Individually.

Dairkee SH, Luciani-Torres G, Moore DH, Jaffee IM, Goodson WH 3rd. Toxicol Sci. 2018 Sep 1;165(1):131-144. doi: 10.1093/toxsci/kfy126. PMID: 29846718 Free PMC article.

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Goodson WH 3rd, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C… See abstract for full author list ➔ Carcinogenesis. 2015 Jun;36 Suppl 1(Suppl 1):S254-96. doi: 10.1093/carcin/bgv039. PMID: 26106142 Free PMC article.

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification.

La Merrill MA, Vandenberg LN, Smith MT, Goodson W, Browne P, Patisaul HB, Guyton KZ, Kortenkamp A, Cogliano VJ, Woodruff TJ, Rieswijk L, Sone H, Korach KS, Gore AC, Zeise L, Zoeller RT. Nat Rev Endocrinol. 2020 Jan;16(1):45-57. doi: 10.1038/s41574-019-0273-8. Epub 2019 Nov 12. PMID: 31719706 Free PMC article.

Exposure to the polyester PET precursor–terephthalic acid induces and perpetuates DNA damage-harboring non-malignant human breast cells.

Luciani-Torres MG, Moore DH, Goodson WH 3rd, Dairkee SH. Carcinogenesis. 2015 Jan;36(1):168-76. doi: 10.1093/carcin/bgu234. Epub 2014 Nov 19. PMID: 25411358 Free PMC article.

The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them.

Smith MT, Guyton KZ, Kleinstreuer N, Borrel A, Cardenas A, Chiu WA, Felsher DW, Gibbons CF, Goodson WH 3rd, Houck KA, Kane AB, La Merrill MA, Lebrec H, Lowe L, McHale CM, Minocherhomji S, Rieswijk L, Sandy MS, Sone H, Wang A, Zhang L, Zeise L, Fielden M. Cancer Epidemiol Biomarkers Prev. 2020 Oct;29(10):1887-1903. doi: 10.1158/1055-9965.EPI-19-1346. Epub 2020 Mar 9. PMID: 32152214 Free PMC article.

Testing the low dose mixtures hypothesis from the Halifax project.

Goodson WH, Lowe L, Gilbertson M, Carpenter DO. Rev Environ Health. 2020 Aug 24;35(4):333-357. doi: 10.1515/reveh-2020-0033. Print 2020 Nov 18. PMID: 32833669 Review.

Using the Key Characteristics of Carcinogens to Develop Research on Chemical Mixtures and Cancer.

Rider CV, McHale CM, Webster TF, Lowe L, Goodson WH 3rd, La Merrill MA, Rice G, Zeise L, Zhang L, Smith MT. Environ Health Perspect. 2021 Mar;129(3):35003. doi: 10.1289/EHP8525. Epub 2021 Mar 30. PMID: 33784186 Free PMC article.

Bisphenol-A-induced inactivation of the p53 axis underlying deregulation of proliferation kinetics, and cell death in non-malignant human breast epithelial cells.

Dairkee SH, Luciani-Torres MG, Moore DH, Goodson WH 3rd. Carcinogenesis. 2013 Mar;34(3):703-12. doi: 10.1093/carcin/bgs379. Epub 2012 Dec 7. PMID: 23222814 Free PMC article.

Activation of the mTOR pathway by low levels of xenoestrogens in breast epithelial cells from high-risk women.

Goodson WH 3rd, Luciani MG, Sayeed SA, Jaffee IM, Moore DH 2nd, Dairkee SH. Carcinogenesis. 2011 Nov;32(11):1724-33. doi: 10.1093/carcin/bgr196. Epub 2011 Sep 1. PMID: 21890461 Free PMC article.